Thank you to everyone who weighed in on my local clinic vs. CCRM dilemma.
You may be wondering where we are with this decision.
Unfortunately, no closer to clarity than we were last week.
My local RE, Dr. M, is now back from vacay and wanted to talk with us. I had a phone consult with him today on my lunch break. A was not on the call as he had to work. However, A is back from the strike team. They put out the big fire in Ventura. Your prayers were much appreciated.
Here's what Dr. M had to say.
1. The 2010 SART data reflected a really bad year for my local clinic and a really good year for CCRM. In 2011, SART data shows the local clinic with a 3.5% higher success rate than CCRM for my age group.
True story. But I take this with a grain of salt because I think CCRM's cases are tougher.
2. In regards to Dr. Surrey's concerns with Diminished Ovarian Reserve, Dr. M said that he looks at FSH (mine was normal), AMH (mine was borderline) and antral follicle count (mine borderline) to predict how a patient's ovaries will respond to stims. We now know that I don't respond well and that I need an aggressive protocol.
Basically, what I take away is that he doesn't think it matters whether I'm borderline DOR or not...as all of this is used to determine protocol. And we already know I need an aggressive one.
3. Dr. M said the reason we tried the long Lupron cycle last time was to suppress my endometriosis. Unfortunately, it suppressed the stims as well. He is recommending the most aggressive protocol for me now - no BCPs, Ganirelix and estrogen patches to synchronize the follicles, and max dose of stims - 225IU Follistim and 225IU Menopur.
I'm a little skeptical because he changed my protocol now that I got a second opinion. Added estrogen patches and removed BCPs. Why? Did the other doctor point out something that he missed? Was he not really feeling 100% with his initial recommendation? I know I have trust issues (my personal baggage) but it makes me wonder.
4. Dr. M does not think I need a sperm fragmentation test. He doesn't see any value in the information it will provide. Plus, it only tests 100 sperm. A has a good sperm count and his motility is fine. His morphology is borderline. But that is why we are doing ICSI. He said that with the roughly 10 eggs he hopes to get...there will be plenty of good sperm to choose from. I said Dr. Surrey would put A on supplements if he saw anything odd with the test. Dr. M said A could take a multi-vitamin.
I'm not sure how I feel about this. He was rather dismissive and I don't really know much about this test to have an opinion one way or the other.
5. The beta integrin 3 conversation was really the most interesting and controversial part of the discussion. Just like Dr. Surrey, Dr. M has also published papers on this topic. He said a whole lot about this subject that would be hard to paraphrase. But here's the gist. The beta integrin 3 test was created in 1950 and it's flawed. Many RE's do not test for this anymore because the tests are often inconclusive. The beta integrin 3 can be absent one month and present the next. Since it is tested by taking a biopsy of your uterine wall, you can't do it the month of your IVF cycle.
He said the study concludes that a lack of beta 3 results in poor prognosis to IVF. But he doesn't think I need the test. He can just put me on letrozole, just in case. He sent me the study but I don't speak medical too well. Here is the conclusion directly from the study.
We report an association between low pregnancy rates in IVF and
an abnormal integrin expression by EMB obtained in a natural cycle.
A lack of integrin expression was highly associated with endometriosis.
Unexplained IVF failure in a subset of women with endometriosis
may be avoidable using a simple 5-day treatment of the
aromatase inhibitor, letrozole. Recognition of the importance of
undiagnosed endometriosis in women with IVF failure,
recurrent pregnancy loss or infertility, offers enhanced opportunities to treat patients
with suspected implantation failure. Based on our findings and previous
studies in IVF, the use aromatase inhibitors
might improve the IVF success rates in a subset of women
with endometriosis. Further, integrin testing may be indicated in
women with unexplained infertility or mild endometriosis to
better define the risk for unanticipated implantation failure with ART.
Great info, right? But to this I say...where was my letrozole before this consult? Why wasn't this being considered before since he knows that I have endometriosis. He said my endo isn't "that" bad so doesn't even think it will be an issue.
6. Dr. M did say that he thinks we should check one more thing. He'd like to measure my growth hormone via an IGF-1 test. If it is low, he will add growth hormone to my protocol.
I haven't been able to find anything on Dr. Google about human growth hormone and infertility so I'm left scratching my head on this one.
7. Lastly, upon my suggestion, he said it wouldn't be imprudent to do a hysteroscopy since it has been a year and four months since my laparoscopy.
In conclusion, Dr. M said it comes down to whether I want to work with him or Dr. Surrey. He did acknowledge that CCRM is one of the best clinics in the country but he also thinks his clinic is good. When I told him that I've heard that CCRM's labs and embryologist are the best. He didn't disagree.
I think I already know in the pit of my stomach what the right decision is. But going to CCRM just feels like starting completely over again from the start. More paperwork. All of the tests over again. So much more money. Sigh. A and I will regroup later this week and make a decision.
In the meantime, has anyone done the Ganirelex/Estrogen patch protocol? What about the letrozole (or Famera)? Any thoughts on Dr. M's perspective versus Dr. Surrey?
P.S. Love you guys for helping me navigate all of this craziness. It helps so much to put it all out there and hear what y'all think.
